Fig. 3
From: TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity
Expression of mRNA levels of genes associated with macrophage activation and inflammation in adipose tissue from vehicle (Veh) and TAK-242 (TAK)-treated mice fed a control (CTL) or high-fat diet (HFD). mRNA from gonadal fat pads was probed for levels of the macrophage markers a CD68 and b F4/80, as well as for the antigen presenting molecules c MHC II and d CD74. Pro-inflammatory cytokine expression was examined by probing for levels of e IL-6, f IL-1β, and g TNFα. Data show fold difference means and standard error of the means (SEM) relative to vehicle-treated mice fed a control diet n = 10/group. Vehicle-treated animals are shown in white bars and TAK-242-treated are shown in black bars. Statistical significance is based on ANOVA followed by Bonferroni correction. *p < 0.05 relative to drug treatment-matched mice in control diet condition. ap < 0.05 for main effect of diet that does not reach statistical significance in between-group comparisons