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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

Fig. 5

Hippocampal mRNA expression of genes associated with activated microglial phenotypes and neuroinflammation in mice fed a control (CTL) or high-fat diet (HFD) and treated with vehicle (Veh) or the TLR4 inhibitor, TAK-242 (TAK). Hippocampal mRNA was probed for levels of the microglia/macrophage markers a CD68 and b F4/80, and for the innate immune antigen presentation markers c MHC II and d CD74. Pro-inflammatory cytokine expression was examined using e IL-6 and f IL-1β. Gene expression of two factors involved in microglial phenotype, lipid transport, and uptake g LPL and h CD36 were also assayed in hippocampus. Data show fold difference means and standard error of the means (SEM) relative to vehicle-treated mice fed a control diet n = 10/group. Vehicle-treated animals are shown in white bars and TAK-242-treated are shown in black bars. Statistical significance is based on ANOVA followed by Bonferroni correction. *p < 0.05 relative to drug treatment-matched mice in control diet condition. #p < 0.05 relative to vehicle-treated mice in same diet condition. bp < 0.05 for main effect of drug treatment that does not reach statistical significance in between-group comparisons

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