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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

Fig. 8

Working memory and cued and contextual memory performance in mice maintained on control (CTL) or high-fat diet (HFD) and given vehicle (Veh) or the TLR4 inhibitor, TAK-242 (TAK). a, b Short-term working memory was assessed by spontaneous alternation behavior. a Total arm entries in the Y maze. b Spontaneous alternation behavior (SAB) in the Y maze. ce Cued and contextual memory was tested in the fear conditioning paradigm. c Learning was assessed by examining freezing behavior during the trace period between the tone and shock on the 5th trial of the training day. d Cued memory was tested 24 h later in a different context. e Contextual memory was assessed 24 h after the cued test. Data are presented as mean (±SEM) values; n = 10–14/group. Vehicle-treated animals are shown in white bars, and TAK-242-treated are shown in black bars. Statistical significance is based on ANOVA followed by Bonferroni correction. *p < 0.05 relative to drug treatment-matched mice in control diet condition

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