Fig. 2

Building a euthyroid HT model in mice. a Representative thyroid sections stained with HE shown at magnification × 50. Con mice displayed a normal thyroid gland. HT mice manifested thyroid enlargement with destroyed thyroid follicles and prominent monocyte infiltration. Arrowhead: thyroid gland; Arrow: infiltrated monocytes. b Quantitation of the degree of monocyte infiltration in thyroids. The analysis was done as described in the Methods. c–g Serum levels of thyroiditis-related parameters, including anti-TPO (c), anti-Tg (d), T3 (e), T4 (f), and TSH (g). Data are presented as the mean ± SEM, n = 10; ns, no statistical significance; ^**p < 0.01, and ^***p < 0.001, vs. Con