Fig. 4

Euthyroid HT induces anxiety-like behavior in mice. The OFT and EPM were used to evaluate anxiety-like states in animals. a–g Behavioral performances in the OFT, including representative path tracings during the OFT (a), entries into the center (b), time spent in the center (c), total distance (d), mean speed (e), number of rearings (f) number of groomings (g). h-l Behavioral performances in the EPM, including representative path tracings during the EPM (h), open-arm time (i), open-arm entries (j), percentage of open/total-arm time (k), and percentage of open/total-arm entries (l). Data are presented as the mean ± SEM, n = 10; ns, no statistical significance; ^**p < 0.05, ^**p < 0.01, and ^***p < 0.001, vs. Con