Fig. 7
From: Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice
Ultrastructural observations of microglia and astrocytes in the frontal cortex. a, b Representative TEM images of microglia. The control group (a) showed an irregular nucleolus with chromatin condensation beneath the nuclear membrane and a primary lysosome (arrow). In contrast, the HT group (b) showed an enlarged nucleolus with increased lysosomes including primary lysosomes (arrows) and secondary lysosomes (arrowheads). Mg, microglia. Magnification × 12,000. c, d Representative TEM images of astrocytes. The control group (c) showed the classical appearance of astrocyte with a narrow rim of chromatin beneath the nuclear membrane. The cytoplasm was pale, contained an endoplasmic reticulum (arrowheads) and a few mitochondria (asterisk). In contrast, the astroglia in the HT group (d) had an organelle-rich cytoplasm that included a well-developed Golgi apparatus (arrow), some endoplasmic reticulum (arrowheads), and many mitochondria (asterisks). As, astroglia. Magnification × 10,000