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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

Fig. 1

ω-3 PUFA supplementation improves neurological function and reduces brain edema after TBI. a Experimental scheme of ω-3 PUFA supplementation after TBI. b A schematic of a brain section after TBI. Areas in red refer to lesioned sites and areas in blue refer to sample points. c ω-3 PUFA supplementation improved neurological functions 3 days after TBI (10.31 ± 0.43 vs 12.03 ± 0.53, p < 0.05). d Rats in the TBI+ω-3 PUFA group showed significantly improved rotarod performances than rats in the TBI groups from day 7 after TBI (72.01 ± 8.21 vs 53.11 ± 7.13, p < 0.05). e ω-3 PUFA supplementation decreased brain water content 3 days after TBI (80.26% ± 0.61% vs 81.92% ± 0.72%, p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01

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