Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

Fig. 5

ω-3 PUFA supplementation protects neurons via inhibition of oxidative stress in lesioned cortices. a, b ω-3 PUFA supplementation decreased ROS activity, while it significantly increased the levels the antioxidants HO-1, NQO1, and UGT1A1 in lesioned cortices. 3-MA attenuated ω-3 PUFA-induced activation of these antioxidant factors. c, d 3-MA reversed ω-3 PUFA-mediated inhibition of neuronal apoptosis and attenuated the neuroprotective effects associated with ω-3 PUFA treatment (p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01

Back to article page