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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

Fig. 7

ω-3 PUFA supplementation elevates SIRT1 expression and deacetylase activity in lesioned cortices 7 days after TBI. a SIRT1 immunoreactivity in both neurons and microglia from lesioned cortices was significantly increased by ω-3 PUFA supplementation (2.64 ± 0.47 vs 1.74 ± 0.33, p < 0.05). b SIRT1 levels were also upregulated after ω-3 PUFA supplementation (p < 0.05). c The NAD+/NADH ratio was measured to detect SIRT1 activity. Treatment with ω-3 PUFA significantly increased the NAD+/NADH ratio (p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01. Scale bars = 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094