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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

Fig. 8

ω-3 PUFA supplementation increases Beclin-1 deacetylation by elevating SIRT1 activity 7 days after TBI. a IP analysis showed an elevation of Beclin-1 deacetylation following ω-3 PUFA supplementation compared with the TBI group (p < 0.05). b The nuclear export of Beclin-1 induced by ω-3 PUFA supplementation was reversed by pharmacological inhibition of SIRT (p < 0.05). c Autophagy activation induced by ω-3 PUFA supplementation was reversed by pharmacological inhibition of SIRT1 (p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01

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