Fig. 1

Schematic illustration of the study design. In vivo β-amyloid small animal positron emission tomography (Aβ-μPET) and 18 kDa translocator protein (TSPO)-μPET imaging was performed in a longitudinal design with baseline examination at 0 months, follow-up at + 2.2 months, and terminal examination at + 6.3 months in the Alzheimer’s disease (AD) mouse model, APP-SL70. Molecular validation of μPET results was performed via immunohistochemistry in mid- (11.4 to 12.7 months) and late-aged (13.6 to 15.3 months) APP-SL70 mice after the final μPET-scan. Custom-written Matlab software was used to quantify histological results