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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Fig. 3

Standardized μPET analysis (Z-scores) TSPO activity and amyloidosis. Standardized TSPO activity (a; quadratic fit, R = 0.68, p < 0.001) and standardized fibrillar amyloidosis (b; quadratic fit, R = 0.86, p < 0.001) indicate an increase with aging. The direct comparison of both standardized tracer signals reveals a decrease in the Z-score differences (TSPO—Aβ) with aging (c; quadratic fit, R = 0.66, p < 0.001). d Exemplary findings of a single APP-SL70 mouse show that microglia response is overwhelmed by ongoing amyloid deposition. N = 16

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Journal of Neuroinflammation

ISSN: 1742-2094