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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

Fig. 6

Microglial brain fraction decreased in the plaque-free cortical brain parenchyma of APP-SL70 mice. a Microglial brain fraction as a function of the distance to the plaque border in APP-SL70 mice (black line) when compared to the mean microglial brain fraction in wildtype (wt) mice (dotted blue line). b Direct comparison of microglial brain fraction of APP-SL70 mice (> 30 μm from plaque borders) and wt mice (mean). Microglial brain fraction is significantly reduced compared to wt mice (p < 0.05, two-tailed Student’s t test). c Iba-1 immunofluorescence staining in a wt mouse aged 16 months in comparison to a double staining of Iba-1 and methoxy-X04 stained plaque in APP-SL70 mouse aged 15 months. Data are presented as mean ± SEM; n = 10–17

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