Fig. 4
From: Partial reduction of microglia does not affect tau pathology in aged mice
Blood vessel measures in PLX treated and untreated mice. a Representative z-stack (50 slices) of fluorescein-dextran labeled blood vessels viewed in vivo through cranial windows in wild-type (WT) and Tg4510 mice (TG). b The total blood vessel volume and c blood vessel length was measured from all images and is presented as a proportion of total imaged volume normalized to cortical thickness to account for atrophy. d Urokinase plasminogen activator (Plau) gene expression was measured by qPCR. e QPCR measurement of plasminogen activation inhibitor (Serpine1) gene expression. All data were analyzed by two-way ANOVA followed by Sidak’s multiple comparisons. Error bars represent means ±Std. Dev. ***p < 0.001; **p < 0.01; *p < 0.05