Fig. 3
From: Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese
Pharmacologic inhibition of NF-kB decreases inflammatory gene expression upon exposure to 100 μM MnCl2. a 1 h pretreatment with the NF-κB inhibitor, Bay 11-7082 (Bay-11) [(E)- 3-(4-methylphenyl) sulfonylprop-2-enenitrile], suppressed expression of inflammatory genes in mixed glia following exposure to 100 μM MnCl2. b MnCl2 exposure in pure astrocytes was less than in mixed glia, as were the inhibitory effects of Bay-11, while the DMSO-vehicle control did not suppress inflammatory gene expression in either cell type. One-way ANOVA analyses performed. Data depicted as ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (n ≥ 4 per treatment group; across ≥ 3 independent experiments)