Fig. 5
From: Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese
Gene deletion of IKK2 in astrocytes decreases inflammatory gene expression following exposure to 100 μM MnCl2 in mixed glial cultures. Astrocyte-specific IKK2 knockout decreases inflammatory mRNA (a) and protein (b) expression of inflammatory genes in mixed glial cultures compared to corresponding WT-treated groups. Two-way ANOVA analyses performed. Data depicted as ± S.E.M. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (n ≥ 4 per treatment group; across ≥ 3 independent experiments)