Fig. 8

Elimination of KCa3.1 in APP/PS1 mice rescues spatial memory deficits in the MWM test. MWM testing of 15-month-old WT, KCa3.1^−/−, APP/PS1, and KCa3.1^−/−/APP/PS1 mice was performed as described in the “Materials and methods” section. a Escape latency. b Number of crossing the target quadrant by each group during the probe trials (no platform). c Percentage of swimming time spent in the target quadrant by each group during the probe trials (no platform). d Percentage of swimming distance spent in the target quadrant by each group during the probe trials (no platform). Data are presented as the mean ± SEM (n = 10–12). #p < 0.05, ##p < 0.01 vs. WT mice. *p < 0.05, **p < 0.01 vs. APP/PS1 mice. WT wild-type