Table 3 Neuroinflammatory gene expression changes in wild-type (WT) and STING^−/− mice at 2 h and 24 h post-TBI

IRF3

1.982 ± 0.269

0.883 ± 0.179

p = 0.7604

2.519 ± 0.496

0.973 ± 0.173

p = 0.0306

IRF7

2.417 ± 0.55

0.954 ± 0.104

p = 0.3106

4.938 ± 0.968

4.014 ± 0.721

p > 0.9999

IFN-α

2.450 ± 0.903

0.024 ± 0.007

p < 0.0001

0.180 ± 0.065

0.174 ± 0.082

p > 0.9999

IFN-β

2.191 ± 0.623

0.077 ± 0.044

p = 0.0492

0.963 ± 0.166

0.372 ± 0.3101

p > 0.9999

TNF-α

173.176 ± 23.243

1.170 ± 0.280

p < 0.0001

30.906 ± 14.556

0.136 ± 0.020

p = 0.6004

IL1-β

62.860 ± 18.641

2.340 ± 0.244

p < 0.0001

15.237 ± 5.301

3.290 ± 2.251

p > 0.9999

IL-6

6.322 ± 1.037

1.679 ± 0.489

p = 0.6419

10.198 ± 4.661

9.126 ± 2.532

p > 0.9999

IRF3

0.715 ± 0.106

0.112 ± 0.039

p > 0.9999

0.856 ± 0.118

0.320 ± 0.053

p > 0.9999

IRF7

0.909 ± 0.130

0.971 ± 0.160

p > 0.9999

1.172 ± 0.148

2.727 ± 0.384

p = 0.1696

IFN-α

0.972 ± 0.394

0.159 ± 0.080

p > 0.9999

0.205 ± 0.133

0.012 ± 0.010

p > 0.9999

IFN-β

0.751 ± 0.231

0.315 ± 0.619

p > 0.9999

1.136 ± 0.534

0.045 ± 0.0268

p > 0.9999

TNF-α

138.223 ± 20.547

3.354 ± 0.868

***p < 0.0001

12.332 ± 4.273

0.388 ± 0.029

p > 0.9999

IL1-β

46.589 ± 10.443

6.324 ± 1.440

***p < 0.0001

3.260 ± 0.536

1.648 ± 0.362

n.s p > 0.9999

IL-6

8.086 ± 1.463

4.342 ± 0.690

p = 0.9244

0.484 ± 0.103

4.722 ± 0.884

p = 0.7951