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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Fig. 8

Effects of preemptive intrathecal administration of endomorphins on gene expression of inflammatory cytokines and chemokines. EM-1 and EM-2 differently reversed CFA-induced regulation of mRNA expression of IL-1β (a), IL-10 (b), TNF-alpha (c), CCL2 (d), and CCL3 (e) in the ipsilateral DRG tissues 1 day after CFA. Results are shown as the fold expression relative to control (n = 8–10 animals/group). *P < 0.05 indicates significant differences compared with Control group according to Mann-Whitney test

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Journal of Neuroinflammation

ISSN: 1742-2094