Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Table 2 Expression or co-expression of MOR and P-p38 MAPK in DRG neurons (%: immunoreactive neurons relative to total DRG neurons)

	Control	Saline + CFA	EM-1 + CFA	EM-2 + CFA
P-p38	7.3 ± 0.9	29.2 ± 3.9 ***	8.2 ± 1.4 ^###	9.4 ± 1.5 ^###
MOR	11.8 ± 1.7	28.9 ± 3.1 ***	—	—
MOR + P-p38	2.6 ± 0.4	17.6 ± 0.8 ***	7.4 ± 0.9 ^###	9.8 ± 0.7 ^###

Quantification illustrates the expression of MOR and P-p38 MAPK and their co-expression in DRG neurons in response to CFA
^***P < 0.001 indicates significant differences compared with Control samples according to one-way ANOVA followed by Bonferroni post-hoc analysis or two-tailed t test
^###P < 0.001 indicates significant differences compared with Saline + CFA samples according to one-way ANOVA followed by Bonferroni post-hoc analysis

ISSN: 1742-2094