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Table 3 Relative mRNA levels of inflammatory mediators in DRG tissues

From: Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

Gene

CFA

Saline + CFA

EM-1 + CFA

EM-2 + CFA

IL-1β

2.46 ± 0.70

3.67 ± 0.61*

1.08 ± 0.16 #

2.33 ± 0.57

IL-10

0.33 ± 0.11**

0.51 ± 0.13*

0.80 ± 0.12

0.77 ± 0.23

TNF-α

2.84 ± 0.41*

2.07 ± 0.60

1.41 ± 0.51

1.21 ± 0.08

CCL2

2.51 ± 0.63

2.91 ± 0.38*

1.25 ± 0.37

1.97 ± 0.61

CCL3

2.20 ± 0.44**

3.03 ± 0.34**

1.21 ± 0.35

2.58 ± 0.63

  1. Inflammatory mediators mRNA levels are assessed by RT-PCR assay and normalized to GAPDH-expression
  2. *P < 0.05 and **P < 0.01 indicates significant differences compared with Control samples according to one-way ANOVA followed by Bonferroni post-hoc analysis
  3. #P < 0.05 indicates significant differences compared with Saline + CFA samples according to one-way ANOVA followed by Bonferroni post-hoc analysis
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Journal of Neuroinflammation

ISSN: 1742-2094