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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes

Fig. 2

Imaging of VZV-infected quiescent primary human spinal cord (qHA-sps) and hippocampal (qHA-hps) astrocytes. At 3 days post-infection, VZV-infected qHA-sps were analyzed by immunofluorescent antibody assay using a mouse anti-VZV glycoprotein B (gB) antibody. Cells expressing VZV gB were identified and examined by enhanced contrast imaging. VZV-infected qHA-sps developed complex cellular processes with filipodia-like projections (a, b, arrows), whereas VZV-infected qHA-hps lacked the complex cellular processes and appeared globular (d, e). Surface plot imaging of VZV-infected qHA-sps demonstrated the network of cellular projections between cells (c), whereas VZV-infected qHA-hps formed islands of swollen, globular cells (f). The blue color indicates cell nuclei. Mag × 630 (a, b, d, and e) and × 400 (c, f)

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