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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways

Fig. 4

M8I inhibited the phosphorylation of MAP kinases and Akt in LTA-stimulated astrocytes. a Western blot analysis for MAP kinases and Akt activities. Cell extracts were prepared from astrocytes treated with LTA (10 μg/ml) for 1 h in the presence or absence of M8I and then subjected to immunoblot analysis using antibodies against the phospho- or total forms of three types of MAPKs or Akt. The autoradiograms are representative of three independent experiments. b Quantification of Western blot data. Levels of the phosphorylated forms of MAP kinases and Akt were normalized with respect to the level of each total form and expressed as relative fold changes versus the control group. The data are the means ± S.E.M. for three independent experiments. #P < 0.05, vs. control samples. *P < 0.05, vs. LTA-treated samples

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