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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways

Fig. 8

M8I increased the expression and nuclear translocation of c-Jun in astrocytes. Cells were treated with M8I in the presence or absence of LTA for 3 h. a The effect of M8I on c-Jun mRNA expression was determined by RT-PCR analysis. b, c The protein levels of c-Jun in b whole cell lysates and c nuclear extracts were determined by Western blot analysis. Quantification data are shown in the bottom panels. The data are the means ± S.E.M. for three independent experiments. #P < 0.05, vs. control samples. *P < 0.05, vs. LTA-treated samples

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Journal of Neuroinflammation

ISSN: 1742-2094