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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration

Fig. 5

Microglia numbers are stable during a dramatic period of cell clearance. a, b CD45low populations were gated on Ly6C and Cx3CR1 expression; MHC-II was used to distinguish microglia from resident macrophages, and CD45-IV was used to remove cells within or associated with the vasculature. c Microglia, the resident MHC-IIlow cells, remained at constant for the first 72 h, then increased at 96 h (lavender). d The number of resident MHC-IIhigh cells was also stable until 96 h (dark purple). Together, these data show that the number of resident immune cells is stable during early retinal degeneration. *p < 0.05, **p < 0.01, ***p < 0.001; error bars are SEM, n = 6–9 retinas per time point

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