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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration

Fig. 6

Infiltrating cells are primarily CCR2+ Ly6Chigh. a, b CD45high populations were gated on Ly6C, Cx3CR1, CCR2, and CD45-IV expression. c The number of Ly6Chigh cells increased dramatically at 24 h and remained high before falling at 72 and 96 h (red). d Ly6Clow cells were less abundant at early times, slowly increasing over the first 48 h before abruptly doubling between 72 and 96 h (blue). e CD45-IV+ populations from retinal samples were examined to determine the Ly6C status of cells trapped within the retinal vasculature (yellow). The number of Ly6Chigh cells increased sharply by 24 h and did not return to baseline by 96 h; the number of Ly6Clow cells increased briefly at 24 h before returning to baseline. *p < 0.05, **p < 0.01, ***p < 0.001; error bars are SEM, n = 6–9 retinas per time point

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