Fig. 1

Schematic illustration of phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation of stroke. Rats of IR were injected PS-MBs, and transcranial US was performed simultaneously. This process transformed PS-MBs into PS-NPs and acquired ultrasound-targeted microbubble destruction to open BBB, which promoted PS-NPs into the ischemic area