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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: The GLP-1 analog, liraglutide prevents the increase of proinflammatory mediators in the hippocampus of male rat pups submitted to maternal perinatal food restriction

Fig. 4

Morphological changes of Iba-1 immunoreactive cells in the hilus of dentate gyrus of the hippocampus. a The upper panel show examples of the morphological types in which cells were classified. Type I, cells with few cellular processes; type II, cells showing four short branches; type III, cells with numerous cell processes and a small cell body; type IV, cells with large somas and retracted and thicker processes; and type V, cells with numerous short processes and intense Iba1 immunostaining. b The graph shows the proportion of reactive cells (types IV and V) in CT/VEH, control pups treated with vehicle; CT/LIRA, control pups treated with liraglutide; MPFR/VEH, food-restricted pups treated with vehicle; and MPFR/LIRA, food-restricted pups treated with liraglutide. Data are mean + SEM. (***p < 0.001 compared to CT/VEH; &&p < 0.01 compared to CT/LIRA; ##p < 0.01 compared to MPFR/VEH)

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Journal of Neuroinflammation

ISSN: 1742-2094