Fig. 1

Disruption of the blood-retina barrier in LPS-challenged mice. Infrared images (a, d, g) and vertical B-scans (b, e, h), at baseline (a, b), at day 4 of the LPS challenge (d, e), and at day 7 after the first LPS challenge (g, h) in Balb/c mice, revealed accumulation of sub-retinal fluid after 4 daily systemic injections of LPS. At higher magnification individual retinal layers can be seen at baseline (c), at day 4 of the LPS challenge (f), and at day 7 after the first LPS challenge (i). Sub-retinal fluid was accumulated in LPS-treated mice at day 4 (f). Fluorescein angiograms at baseline (j), at day 4 of the LPS challenge (k), and at day 7 after the first LPS challenge (l) revealed fluorescein leakage in LPS-treated mice at day 4 (k). Arrows correspond to the leakage area. Location of B-scans in b, e, and h is indicated with the middle line in a, d, g, respectively. One representative retina out of ≥ 8 is presented for each time point. A, artery; INL, inner nuclear layer; IPL, inner plexiform layer; OD, optic disk; ONL, outer nuclear layer; OPL, outer plexiform layer; PIS/POS, photoreceptor inner segments/photoreceptor outer segments; RNFL, retinal nerve fiber layer; RPE, retinal pigment epithelium; V, vein