Fig. 3

IL-33 and soluble receptor in serum of patients with Alzheimer’s disease. The circulating levels of ligands and soluble receptors of the factors of the IL-33 sub-system were assessed in serum of normal healthy subjects (NHS) in comparison with those detected in serum of patients with subjective memory complaints (SMC), mild cognitive impairment (MCI), and patients with Alzheimer’s disease (AD). The factors tested are IL-33 (upper panel) and sIL-1R4 (lower panel). Please note that the third component of the sub-system, the soluble accessory receptor chain sIL-1R3, is already reported in Fig. 1, as it is common to both the IL-1 and the IL-33 sub-systems. Statistically significant differences are indicated. All other comparisons are statistically not significant