Table 2 Variations of IL-1 family cytokines and receptors in AD patients and other diseases vs. healthy controls
IL-1 family molecule | Disease | |||||
|---|---|---|---|---|---|---|
AD | MCI | SMC | ALS | SLE | IgG4-RD | |
IL-1 subsystem | ||||||
IL-1α | ↑ | = | = | n.t. | = | = |
IL-1β | ↑ | = | = | = | = | = |
IL-1Ra | ↑ | = | = | = | = | = |
sIL-1R1 | ↑ | = | ↓ | n.t. | = | ↑ |
sIL-1R2 | = | ↑ | ↓ | = | = | ↑ |
sIL-1R3 | ↑ | = | ↑ | n.t. | = | ↓ |
IL-18 subsystem | ||||||
IL-18 | = | = | ↓ | ↑ | ↑ | = |
IL-18BP | ↑ | ↓ | ↓ | ↑ | ↑ | = |
Free IL-18 | = | ↑ | = | ↑ | ↑ | = |
IL-33 subsystem | ||||||
IL-33 | ↑ | = | = | = | ↓ | = |
sIL-1R4 | ↑ | = | = | = | ↑ | ↑ |
sIL-1R3 | ↑ | = | ↑ | n.t. | = | ↓ |