Fig. 2

Celecoxib ameliorated depression-like behaviors in a rat model of depression. a Treatment of celecoxib (20 mg/kg) or fluoxetine (40 mg/kg) reversed the decreases in percent of sucrose consumption of CUMS rats. b Treatment of celecoxib (40 mg/kg) reversed the increases in immobility times and decreases in swimming times of CUMS rats in the forced swim test. c Treatment of celecoxib (40 mg/kg) reversed the decreases in percentage of sucrose consumption of rats subjected to LPS-induced depression. d Treatment of celecoxib (40 mg/kg) reversed the increases in immobility times and decreases in swimming times of rats subjected to LPS-induced depression. All values are presented as means ± SEM (N = 18). *P < 0.05, **P < 0.01, ***P < 0.001 CUMS (or LPS) vs control group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 CUMS (or LPS)+Cele vs depression group; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001 CUMS (or LPS)+FLX vs depression group (Cele, celecoxib; FLX, fluoxetine)