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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

Fig. 5

Overexpression of βCaMKII activates the COX-2/PGE2 pathway within the CA1 region of wild-type rats. a Western blot analysis of COX-2 protein levels in CA1 regions of rats infected by AAV-βCaMKII. b QPCR analysis of COX-2 mRNA in CA1 regions of rats infected by AAV-βCaMKII. c Content assays showing expressions of PGE2 in CA1 regions of rats infected by AAV-βCaMKII. d Western blot analysis of p38, p-p38, p-CREB, and p-ATF2 expression levels in CA1 regions of rats infected by AAV-βCaMKII. N = 6 per group. Data are presented as the means ± SEM. *P < 0.05, **P < 0.01 WT+AAV-βCaMKII vs WT; #P < 0.05, ##P < 0.01 WT+AAV-βCaMKII vs WT+AAV-control (WT, wild type)

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Journal of Neuroinflammation

ISSN: 1742-2094