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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

Fig. 7

Knocking down of βCaMKII in CA1 suppresses hyperactivity of the COX-2/PGE2 pathway in depressed rats. a Western blot analysis of COX-2 protein levels in CA1 infected by AAV-βCaMKII RNAi. b QPCR analysis of COX-2 mRNA in CA1 regions. c Content assays showing expressions of PGE2 in CA1 regions. d Western blot analysis of p38, p-p38, p-CREB, and p-ATF2 expression levels in CA1 regions. N = 6 per group. Data are presented as the means ± SEM. *P < 0.05, **P < 0.01 CUMS+AAV-βi vs CUMS; #P < 0.05, ##P < 0.01 CUMS+AAV-βi vs CUMS+AAV-control (AAV-βi, AAV-βCaMKII RNAi)

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Journal of Neuroinflammation

ISSN: 1742-2094