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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

Fig. 8

Blocking p38 MAPK reduces activity of the COX-2/PGE2 pathway and depression-like behaviors in rats. a, b Pretreatment of SB203580 (10 μg/kg) ameliorated the depression-like behaviors in CUMS rats. c Pretreatment of SB203580 reversed the decreased phosphorylation levels of CREB, ATF2, and COX-2 expression in CA1 caused by CUMS exposure. d SB203580 attenuated the increased COX-2 mRNA levels in CA1 resulting from CUMS exposure. e SB203580 reduced the morphological changes of microglia and astrocytes within the CA1 resulting from CUMS exposure. f SB203580 attenuated the increased PGE2 content levels in CA1 resulting from CUMS exposure. g SB203580 reduced the increased Iba1 protein levels within the CA1 resulting from CUMS exposure. h SB203580 reduced the increased GFAP protein levels within the CA1 resulting from CUMS exposure. N = 6 per group. Data are presented as the means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 CUMS vs control group; #P < 0.05, ##P < 0.01, ###P < 0.001 CUMS+SB203580 vs CUMS group (SB, SB203580)

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