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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation

Fig. 12

Schematic summarizing sequential alteration in astrocytes and microglia in the VPL 14 and 28 days after spinal nerve ligation (SNL). The VPL is delineated in black on Figure 56 (interaural 6.24 mm, Bregma − 2.76 mm) from the atlas of Paxinos and Watson [48]. Schemas of astrocytes appear in red (GFAP immunolabeling) and schemas of microglia (iba-1immunolabelling) appear in green. We found that GFAP immunostaining area was increased at D28 in the VPL of SNL as compared to the one of naïve rats while the number of GFAP/S100β immunopositive cells was unchanged. At D14, the iba-1 immunostaining area and the number of iba-1 immunopositive cells were decreased in the VPL of SNL as compared to the one of naïve rats. Finally, we found a sequential increase in mRNA expression of cathepsin S (D14), fractalkine (CX3CL1, D28), and fractalkine receptor (CX3CR1, D14, also increase in protein expression), well-known markers of microglial reactivity

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