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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes

Fig. 3

Circularity of Iba1-positive cells after photothrombotic stroke. This parameter was measured in ROIs as defined in Fig. 2a. a Comparison of Iba1-immunolabeled cells in peri-infarct tissue (Ipsi01A) and equivalent tissue (Contra01) in the hemisphere contralateral to the infarct at 3 h after stroke induction. The scale bar = 100 μm. b Regional differences at 3 h. Insets show examples of processed images of Iba1-positive cells at an ROI adjacent to the infarct (Ipsi01A) and in corresponding contralateral tissue (Contra01). c Regional differences at 24 h. Inset shows an example of a processed image at Ipsi01A. d Time course of changes in peri-infarct regions (Ipsi01A and Ipsi01B), tissue 1 mm from the infarct (ipsi01A + 1 mm) and corresponding contralateral tissue (Contra01) over the first 7 days. For panels b–d, n = 4 for each data point; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the corresponding contralateral region (one-way ANOVA with Tukey’s HSD post-hoc test)

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