Fig. 1
From: Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
Leukocyte populations in lymphoid organs of the triple transgenic (3xTg-AD) model. a Quantification of leukocyte and lymphocyte subpopulations in the spleen of 3xTg-AD mice by flow cytometry revealed similar concentrations of B and T lymphocytes compared to non-transgenic animals (NTg). b Enumeration of bone marrow cells indicates comparable proportions of B and T lymphocytes, monocytes, granulocytes, and long-term reconstituting (LTR) but reduction of short-term reconstituting (STR) hematopoietic stem cells. Data are presented as mean ± SEM (N = 8 NTg and N = 12 3xTg-AD 12-month-old animals per group, N are indicated on the graphs). Statistical analysis: Refer to Table 1. Mann-Whitney test (non-parametric) and Welch’s t test (parametric) was performed. *P = 0.0116 compared to NTg