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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET

Fig. 1

Higher [11C]DPA-713 regional total distribution volume (VT) values were found in 12 participants with post-treatment Lyme disease symptoms (< 6 months) or syndrome, compared to 19 healthy control participants, accounting for TSPO genotype (C/C vs. C/T). a Boxplot diagram of [11C]DPA-713 VT across eight regions of interest from healthy controls (white data) and participants with PTLDS (gray data) that were grouped by TSPO genotype (C/C, upper panel; C/T, lower panel). A linear mixed effects regression model adjusting for TSPO genotype, brain region, and factors with found effects on binding (age, BMI) demonstrated higher VT in the patients compared to the controls. *In secondary analyses, a regional difference was found between patients and controls using individual linear regression models fit for the region of interest and controlling for age, BMI, and genotype. These differences in individual regions did not remain significant after Bonferroni correction for the eight regions tested, which required P < 0.05/8 ≈ 0.006. b Mean parametric [11C]DPA-713 VT images, displayed within each group (control, patient) in axial, sagittal, coronal views (left to right) and by TSPO genotype (C/C, upper panel; C/T, lower panel), demonstrate higher mean VT in patients compared to controls. Within the study population, participants with C/C genotype included 13 controls and four patients, and those with C/T genotype included six controls and eight patients. VT is in units of mL cm−3

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