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Table 1 Demographic characteristics and PET parameters across the study population

From: Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET

 

Healthy controls (N = 19)

Patients with persistent symptoms following treated Lyme disease (N = 12)

P a

Age, years

51.0 [38.5, 56.0] (22.0, 62.0)

42.0 [39.5, 47.3] (24.0, 63.0)

0.361

Sex, male

13 (68.4%)

5 (41.7%)

0.262

Race

0.002

 White

8 (42.1%)

12 (100.0%)

 

 Black

10 (52.6%)

0 (0.0%)

 

 Mixed

1 (5.3%)

0 (0.0%)

 

Body mass index

27.7 ± 4.1 (20.6, 34.0)

25.8 ± 3.8 (20.8, 33.2)

0.193

Genotype, C/T

6 (31.6%)

8 (66.7%)

0.075

Injected dose (MBq)

692.3 ± 20.4

691.4 ± 15.3

0.886

Injected mass (μg)

1.0 ± 0.4

1.0 ± 0.5

0.839

Specific activity (GBq/μmol)

293.6 ± 177.8

310.4 ± 101.1

0.741

Regional volume ratiob

 Cerebellum

0.063 ± 0.009 (0.049, 0.080)

0.073 ± 0.005 (0.065, 0.081)

< 0.001

 Hippocampus

0.006 ± 0.001 (0.005, 0.007)

0.006 ± 0.000 (0.005, 0.006)

0.363

 Occipital Cortex

0.030 ± 0.003 (0.025, 0.037)

0.028 ± 0.004 (0.017, 0.033)

0.072

 Frontal cortex

0.111 [0.107, 0.114] (0.085, 0.125)

0.111 [0.109, 0.114] (0.058, 0.122)

0.984

 Parietal cortex

0.074 [0.067, 0.077] (0.060, 0.086)

0.074 [0.070, 0.076] (0.034, 0.078)

0.826

 Thalamus

0.011 [0.010, 0.011] (0.008, 0.012)

0.010 [0.010, 0.011] (0.010, 0.014)

0.889

 Temporal cortex

0.063 [0.061, 0.067] (0.050, 0.076)

0.063 [0.061, 0.065] (0.021, 0.072)

0.826

 Cingulate cortex

0.013 [0.012, 0.014] (0.011, 0.015)

0.013 [0.013, 0.014] (0.003, 0.015)

0.704

  1. Data from normally distributed continuous variables are presented as mean ± standard deviation (range) and from continuous variables not normally distributed as median [25th percentile, 75th percentile] (range). Data from categorical variables are presented as count (%). aComparison between groups were conducted using Fisher’s exact tests for categorical variables, and t tests or Wilcoxon rank sum tests for continuous variables as appropriate. bRegional volume ratios are equivalent to the volume of each region normalized to total intracranial volume and are unitless