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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury

Fig. 5

Astrocytes labeled with GFAP antibody in the frontal cortex and hippocampus. a Representive images of GFAP-postive cells in the frontal cortex and CA1 and CA3 region of the hippocampus. b A significant reduction in GFAP-positive cells was seen in TBI + MSCs (***p < 0.001) and TBI + MSCs + IL-10 (***p < 0.001) groups in the frontal cortex in comparison to TBI + vehicle group. c In the CA1 region of the hippocampus, a significant reduction of GFAP-positive cells were found in the TBI + MSCs + IL-10 (***p < 0.001) and sham + vehicle group (*p < 0.05) in comparison to TBI + vehicle group. d In the CA3 region of the hippocampus, TBI + vehicle group had a significant increase in GFAP-positive cells when compared to all other groups (*p < 0.05, **p < 0.01; scale bar = 50 μm). Error bars represent ± SEM

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