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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia

Fig. 4

Downregulation of RhoE, Tiam1, and IκBα enhanced microglia migration. Primary microglia were transfected with two individual siRNA oligonucleotides against the indicated target genes for 3 days and then treated with CM. Scrambled siRNA was used as control. Cell migration was determined in a 24-h scratch assay. a Representative images of the scratch width at 1 and 24 h are shown. b The scratch width at 24 h was determined as a percentage of the original scratch width at 1 h and then expressed relative to the scratch width of the Scrambled siRNA-transfected cells (normalized to 1.0) in each experiment. Data are mean ± SEM of at least three independent experiments.*p < 0.05, **p < 0.01, ***p < 0.001 vs. Scrambled siRNA

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