Table 1 Validation of siRNA targets resulting in positive differential circularity
siRNA | Differential circularity | P value | FDR |
|---|---|---|---|
Tiam1 #1 | 2.73 | < 10 −16 | < 10 −14 |
Creb1 #2 | 2.55 | < 10 −14 | < 10 −11 |
p38β #3 | 2.22 | < 10 −11 | < 10 −10 |
Tiam1 #2 | 2.06 | < 10 −10 | < 10 −9 |
RhoE #1 | 1.93 | < 10 −9 | < 10 −8 |
Arhgef4 #2 | 1.84 | < 10 −8 | < 10 −7 |
p38β #2 | 1.79 | < 10 −8 | < 10 −7 |
Creb1 #1 | 1.71 | < 10 −7 | < 10 −6 |
Map3k2 #1 | 1.64 | < 10 −6 | < 10 −6 |
Map3k2 #3 | 1.52 | < 10 −6 | < 10 −5 |
IκBα #2 | 1.46 | < 10 −5 | < 10 −5 |
GM-CSFR #1 | 1.44 | < 10 −5 | < 10 −5 |
IκBα #1 | 1.40 | < 10 −5 | < 10 −4 |
Map3k2 #2 | 1.36 | < 10 −5 | < 10 −4 |
Tiam1 #3 | 1.26 | < 10 −4 | < 10 −4 |
p38β #3 | 1.19 | < 10 −4 | < 0.01 |
RhoE #2 | 1.15 | < 0.001 | < 0.01 |
JNK2 #3 | 1.08 | < 0.001 | < 0.01 |
Creb1 #3 | 1.01 | < 0.001 | < 0.01 |
Arhgef4 #1 | 0.90 | < 0.01 | < 0.01 |
GM-CSFR #2 | 0.83 | < 0.01 | < 0.01 |
RhoE #3 | 0.73 | < 0.05 | < 0.05 |
MEK3 #2 | 0.58 | 0.05 | 0.07 |
Arhgef4 #3 | − 0.55 | 0.06 | 0.08 |
GM-CSFR #3 | 0.42 | 0.16 | 0.21 |
MEK3 #3 | − 0.32 | 0.28 | 0.35 |
IκBα #3 | 0.28 | 0.34 | 0.40 |
MEK3 #1 | 0.16 | 0.58 | 0.64 |
JNK2 #1 | − 0.11 | 0.70 | 0.75 |
JNK2 #2 | − 0.08 | 0.80 | 0.82 |