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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke

Fig. 4

Relationship between cav-1 and free radicals. On one hand, cav-1 directly binds to NOS and decreases NO; on the other hand, NO negatively regulates cav-1 expression. Cav-1 reduces the production of ROS via inhibiting the activity of NADPH oxidases (NOX) and (or) promoting SHP-2 activation. NO and ROS can activate MMP-2 and MMP-9, disrupting TJ and ECM, finally inducing BBB hyperpermeability. Thus, cav-1 can inhibit the activity of MMP2 and MMP9 through reducing NO and ROS. Ischemic stroke (IS), NADPH oxidases (NOX), Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2)

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