Fig. 8

Combined administration of fluoxetine and TAK-242 did not enhance the effects of fluoxetine in the expression of TLR4, MyD88, nuclear NF-κB, and pro-inflammatory cytokines, BBB disruption, and neurological function. a Representative western blot bands of TLR4, MyD88, and nuclear NF-κB p65. b Densitometric quantification of TLR4. **p < 0.01 vs SAH+vehicle. n = 6/group. c Densitometric quantification of MyD88. **p < 0.01 vs SAH+vehicle. n = 6/group. d Densitometric quantification of nuclear NF-κB p65. **p < 0.01 vs SAH+vehicle. n = 6/group. e The quantification of TNF-α mRNA levels. **p < 0.01 vs SAH+vehicle. n = 5/group f The quantification of IL-1β mRNA levels. *p < 0.05 vs SAH+vehicle. n = 5/group. g The quantification of IL-6 mRNA levels. **p < 0.01 vs SAH+vehicle. n = 5/group. h The quantification of Evans blue extravasation. **p < 0.01vs SAH+vehicle. n = 6/group. i The quantification of neurological score. *p < 0.05 vs sham. ^#p < 0.05 vs SAH + vehicle. n = 17/group