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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging

Fig. 4

The role of M/Ms in the development of melanoma brain metastases. a Representative fluorescent images of the presence of M/Ms after specific depletion by PLX3397. Normal: mice fed with standard diet without PLX3397. PLX: mice fed with standard diet formulated with PLX3397. Green: EGFP, blue: DAPI. Scale bar: 20 μm. b Quantitative results for the fluorescent images shown in (a). Control: mice before feeding with any diet; n = 25 images from 3 mice per group. c Representative photograph of brain tissues of mice after M/M elimination. d–e The number (d) and size (e) of melanoma brain metastases in the indicated groups; n = 7 mice in the normal group, n = 6 mice in the PLX-treated group. The data are presented as the mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094