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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging

Fig. 6

Verification of the role of MMP3 in melanoma brain metastases. a Representative immunofluorescence images of MMP3 expression by M/Ms after PD166793 treatment. Normal: mice treated with 0.5% CMC without PD166793. PD: mice treated with PD166793 dissolved in 0.5% CMC. Scale bar: 20 μm. b Quantitative results for the proportion of MMP3+ M/Ms shown in (a); n = 13 images from the normal group and 9 images from the PD group, 3 mice per group. c Representative immunofluorescence image of ZO-1 expression in the brain after MMP3 inhibition. Scale bar: 20 μm. d Quantitative results for the proportion of ZO-1+ cells shown in (c); n = 12 images from the normal group and 7 images from the PD group, 3 mice per group. e Representative photograph of brain tissues after PD166793 treatment. f–g The number (f) and size (g) of melanoma brain metastases in the indicated groups; n = 9 mice per group. The data are presented as the mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094