Fig. 6

Loss of Par1b increases microglia activation in response to controlled cortical impact injury in mice. a Representative 20× confocal images of the parietal association cortex around the impact region in CCI, sham-operated, and naïve control Par1b WT (+/+) and Het (+/−) mice 7 days post-surgery. The brains were sectioned and immunostained for microglia marker Iba1 (red) and DAPI (blue). Scale bar = 50 μm. b Quantification of microglial density, n = Par1b (+/+): naïve (5), sham (3), TBI (6); Par1b (+/−):naïve (3), sham (3), TBI (6), *p < 0.05, ***p < 0.001 by two-way ANOVA. c Quantification of fluorescent intensity of Iba1+ cells, n (animals) = Par1b (+/+): naïve (5), sham (3), TBI (6); Par1b (+/−): naïve (3), sham (3), TBI (6)), *p < 0.05, **p < 0.01, ***p < 0.001 by two-way ANOVA