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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury

Fig. 6

Bifunctional immunosuppressive mechanism of RTL, DRα1-MOG-35-55, and DRQ. Graphic shows dual interactions of partial MHC constructs that simultaneously reduce TCR signaling to enhance IL-10 secretion by MOG-35-55-specific T cells and competitively inhibit MIF and D-DT binding and signaling through CD74 on macrophages and dendritic cells. Original figure

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Journal of Neuroinflammation

ISSN: 1742-2094