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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch

Fig. 3

BMSCs treatment suppressed microglial activation and downregulated production of inflammatory cytokines IL-6, IL-1β, and TNF-α at 24 and 72 h post-SAH. Representative images of ionized calcium binding adapter molecule1 (Iba1)- and CD68-positive cells in the Sham, SAH + PBS, and SAH + BMSCs groups (a). BMSCs treatment decreased the expression of pro-inflammatory cytokines, IL-6 (b), IL-1β (c), and TNF-α (d) but elevated the expression of anti-inflammatory cytokine, IL-10 (e) in brain tissue both at 24 and 72 h post-SAH; n = 6 in each group; data are expressed as the mean ± SEM. **P < 0.01, ***P < 0.001 versus Sham, ##P < 0.01,###P < 0.001 versus SAH + PBS group. Scale bar = 50 μm

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